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. 2012 Jun;61(6):794-7.
doi: 10.1136/gutjnl-2012-302014. Epub 2012 Apr 5.

Colorectal cancer: a tale of two sides or a continuum?

Mai Yamauchi  1 , Paul Lochhead, Teppei Morikawa, Curtis Huttenhower, Andrew T Chan, Edward Giovannucci, Charles Fuchs, Shuji Ogino
Affiliations

Colorectal cancer: a tale of two sides or a continuum?

Mai Yamauchi et al. Gut. 2012 Jun.
No abstract available

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Conflict of interest statement

Competing Interests: None directly relevant to this work.

Figures

Figure 1
Figure 1
Illustration of the disparity between the continuum model and the two-colon concept. The frequencies of molecular features such as CIMP-high, MSI-high, and BRAF mutation increase linearly from the rectum to the ascending colon according to the continuum model, and as supported by our recent data (left).[15] Previous studies have typically lumped together all distal tumours, and all proximal tumours, and compared the frequencies of various molecular features. Data from numerous previous two-colon studies appear to support the two-colon concept (right, top), even where the likelihood is that a continuum exists for the measured marker along proximal-distal axis of the bowel (right, bottom). The design of two-colon studies does not permit adequate evaluation of the linearity of marker frequency by colon subsite.
See this image and copyright information in PMC

Comment in

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