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Comment
. 2012 Nov;61(11):1642-3.
doi: 10.1136/gutjnl-2012-302137. Epub 2012 Apr 5.

Dysbiosis modulates capacity for bile acid modification in the gut microbiomes of patients with inflammatory bowel disease: a mechanism and marker of disease?

Free PMC article
Comment

Dysbiosis modulates capacity for bile acid modification in the gut microbiomes of patients with inflammatory bowel disease: a mechanism and marker of disease?

Lesley A Ogilvie et al. Gut. 2012 Nov.
Free PMC article
No abstract available

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Conflict of interest statement

Competing interests: None.

Figures

Figure 1
Figure 1
Bile salt hydrolase (BSH) relative abundance profiles for major phylogenetic divisions in the human gut microbiota. ACT, Actinobacteria; BACT, Bacteroidetes; FIRM, Firmicutes; TOTAL, BSH-like relative abundance in complete MetaHIT dataset regardless of phylogenetic affiliation. ALL MH, complete MetaHIT dataset, HEALTHY, healthy individuals only, UC, individuals with ulcerative colitis only, CD, individuals with Crohn's disease only. Error bars indicate SEM. Level of significance in χ2 distribution analysis: *p<0.01, **p<0.001. Inset table shows relative abundance, within complete MH dataset, for other phylogenetic divisions with which BSH-like homologues were affiliated. Brackets denote SEM.

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References

    1. Gadaleta RM, van Erpecum KJ, Oldenburg B, et al. Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease. Gut 2011;60:463–72 - PubMed
    1. Thomas C, Pellicciari R, Pruzanski M, et al. Targeting bile-acid signalling for metabolic diseases. Nat Rev Drug Discov 2008;7:678–93 - PubMed
    1. O'Keefe SJD. Nutrition and colonic health: the critical role of the microbiota. Curr Opin Gastroen 2008;24:51–8 - PubMed
    1. Ridlon JM, Kang DJ, Hylemon PB. Bile salt biotransformations by human intestinal bacteria. J Lipid Res 2006;47:241–59 - PubMed
    1. Jones BV, Begley M, Hill C, et al. Functional and comparative metagenomic analysis of bile salt hydrolase activity in the human gut microbiome. Proc Natl Acad Sci USA 2008;105:13580–5 - PMC - PubMed

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