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Comment
. 2012 May 2;31(9):2061-3.
doi: 10.1038/emboj.2012.90. Epub 2012 Apr 10.

The many functions of cohesin--different rings to rule them all?

Jan-Michael Peters  1
Affiliations
Comment

The many functions of cohesin--different rings to rule them all?

Jan-Michael Peters. EMBO J. .

Abstract

EMBO J 31 9, 2076–2089 March 13 2012

EMBO J 31 9, 2090–2102 March 13 2012

It is well known that somatic and germ cells use different cohesin complexes to mediate sister chromatid cohesion, but why different isoforms of cohesin also co-exist within somatic vertebrate cells has remained a mystery. Two papers in this issue of The EMBO Journal have begun to address this question by analysing mouse cells lacking SA1, an isoform of a specific cohesin subunit.

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Conflict of interest statement

The author declares that he has no conflict of interest.

Figures

Figure 1
Figure 1
Schematic drawing illustrating how the SA1 and SA2 proteins interact in a mutually exclusive manner with three core subunits of cohesin (Smc1, Smc3, Rad21) that form a ring-like structure. It has been proposed that these complexes mediate cohesion by trapping the two sister DNA molecules inside the cohesin ring (above), and that cohesin rings might affect chromatin structure by forming or stabilizing intra-chromatid loops (below). Cohesin is thought to influence gene regulation at least in part by mediating chromatin looping.
See this image and copyright information in PMC

Comment on

References

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