Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2012 Apr;5(4):503-6.
doi: 10.1158/1940-6207.CAPR-12-0085.

Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells

Frédéric Bost  1 , Issam Ben-Sahra, Jean-François Tanti
Affiliations
Comment

Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells

Frédéric Bost et al. Cancer Prev Res (Phila). 2012 Apr.

Abstract

Several experimental and epidemiologic studies have shown that the antidiabetes drug metformin has antitumor properties. The report by Algire and colleagues in this issue of the journal (beginning on page 536) shows for the first time that metformin reduces mutagenesis induced by reactive oxygen species. This report offers new perspectives on metformin in cancer prevention and provides a new mechanism for the reduction of cancer risk in diabetic patients treated with this drug.

PubMed Disclaimer

Comment on

LinkOut - more resources