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Case Reports
. 2013 Mar;182(1):135-7.
doi: 10.1007/s11845-012-0821-x. Epub 2012 Apr 11.

A series of patients on anti-TNF therapy referred to a multidisciplinary lung cancer service

C O'Connell  1 , M Hensey, A B Mongey, D J Veale, S C Donnelly
Affiliations
Case Reports

A series of patients on anti-TNF therapy referred to a multidisciplinary lung cancer service

C O'Connell et al. Ir J Med Sci. 2013 Mar.

Abstract

Background: Biological therapies have significantly improved the quality of life of patients with aggressive collagen vascular diseases. Blocking TNF activity may potentially confer a higher malignant potential for patients.

Aims: To identify patients to whom anti-TNF therapies were recently prescribed and were referred to a multidisciplinary lung cancer service.

Methods: Retrospective review of patients over an 18-month period who were referred to a multidisciplinary lung cancer service.

Results: Three patients who underwent recent anti-TNF therapies and presented with solid organ tumours. All had significant additional risks for cancer including smoking and family history and active connective tissue diseases with a past history of immunosuppressive therapies.

Conclusions: Our series highlights the potential malignant risk of anti-TNF theraphy to a general medical audience.

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References

    1. Annu Rev Immunol. 1989;7:625-55 - PubMed
    1. Nutr Rev. 1988 Nov;46(11):389-91 - PubMed
    1. Ann Rheum Dis. 2010 Mar;69(3):624-5 - PubMed
    1. Arthritis Rheum. 2002 Dec;46(12):3151-8 - PubMed
    1. Pharmacoepidemiol Drug Saf. 2011 Feb;20(2):119-30 - PubMed

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