Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2012 May;59(5):908-10.
doi: 10.1161/HYPERTENSIONAHA.111.186494. Epub 2012 Apr 9.

Heart rate reduction: an old and novel candidate heart failure therapy

Yonggang Ma, Robert J Chilton, Merry L Lindsey
Editorial

Heart rate reduction: an old and novel candidate heart failure therapy

Yonggang Ma et al. Hypertension. 2012 May.
No abstract available

PubMed Disclaimer

Figures

Figure
Figure
Summary of the differential effects of ivabradine and metoprolol on left ventricular (LV) remodeling and dysfunction in angiotensin II–stimulated heart failure. Ivabradine-specific effects are denoted in the green circle, with factors tested in this study in white. Metoprolol-specific effects are denoted in the red circle. Effects that overlap in the 2 agents are denoted in the gray ellipse. The black font denotes effects that have been studied previously but were not evaluated in the study by Moritz Becher et al.
See this image and copyright information in PMC

Comment on

References

    1. Mulder P, Barbier S, Chagraoui A, Richard V, Henry JP, Lallemand F, Renet S, Lerebours G, Mahlberg-Gaudin F, Thuillez C. Long-term heart rate reduction induced by the selective i(f) current inhibitor ivabradine improves left ventricular function and intrinsic myocardial structure in congestive heart failure. Circulation. 2004;109:1674–1679. - PubMed
    1. Becher PM, Lindner D, Miteva K, Savvatis K, Zietsch C, Schmack B, Van Linthout S, Westermann D, Schultheiss H-P, Tschöpe C. Role of heart rate reduction in the prevention of experimental heart failure: comparison between If-channel blockade and β-receptor blockade. Hypertension. 2012;59:949–957. - PubMed
    1. Savelieva I, Camm AJ. I f inhibition with ivabradine: electrophysiological effects and safety. Drug Saf. 2008;31:95–107. - PubMed
    1. Lauzier B, Vaillant F, Gelinas R, Bouchard B, Brownsey R, Thorin E, Tardif JC, Des Rosiers C. Ivabradine reduces heart rate while preserving metabolic fluxes and energy status of healthy normoxic working hearts. Am J Physiol Heart Circ Physiol. 2011;300:H845–H852. - PMC - PubMed
    1. Walcher T, Bernhardt P, Vasic D, Bach H, Durst R, Rottbauer W, Walcher D. Ivabradine reduces chemokine-induced CD4-positive lymphocyte migration. Mediators Inflamm. 2010;2010:751313. - PMC - PubMed

Publication types

MeSH terms