BRAF mutation: supporting diversity in HCL
- PMID: 22493212
- DOI: 10.1182/blood-2012-01-403659
BRAF mutation: supporting diversity in HCL
Abstract
In this issue of Blood, Xi and colleagues report on v-raf murine sarcoma viral oncogene homolog B1 (BRAF) mutations in hairy cell leukemia (HCL) subsets, demonstrating that BRAF V600E mutations are absent in variant HCL forms and in a subset of classic HCL (HCLc).
Comment on
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Both variant and IGHV4-34-expressing hairy cell leukemia lack the BRAF V600E mutation.Blood. 2012 Apr 5;119(14):3330-2. doi: 10.1182/blood-2011-09-379339. Epub 2011 Dec 30. Blood. 2012. PMID: 22210875 Free PMC article.
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