Aβ and C(lot), but not D(egradation)
- PMID: 22493214
- DOI: 10.1182/blood-2012-02-406660
Aβ and C(lot), but not D(egradation)
Abstract
In this issue of Blood, Zamolodchikov and Strickland examine the association of β-amyloid (Aβ) peptide with fibrin(ogen). These findings shed new light on the relationship between Alzheimer disease and cardiovascular disease, as well as on a novel biochemical mechanism regulating clot stability and dissolution.
Comment on
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Aβ delays fibrin clot lysis by altering fibrin structure and attenuating plasminogen binding to fibrin.Blood. 2012 Apr 5;119(14):3342-51. doi: 10.1182/blood-2011-11-389668. Epub 2012 Jan 11. Blood. 2012. PMID: 22238323 Free PMC article.
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