Review
The complement system. Activation, modulation, and clinical relevance
Affiliations
- PMID: 2249355
Item in Clipboard
Review
The complement system. Activation, modulation, and clinical relevance
Dermatol Clin.
1990 Oct.
Abstract
Activation of the classic or the alternative pathway of the complement system results in the generation of biologically active products and the assembly of MAC. Homeostasis is achieved by the presence of control proteins that modulate the activation at various levels. Complement proteins play an important role in the pathogenesis of several dermatologic disorders. Their deficiency is associated with impairment of host-defense; uncontrolled activation of the system results in the development of angioedema or chronic hemolysis.
Similar articles
-
Non-linear dynamics of the complement system activation.Math Biosci. 2009 Dec;222(2):127-43. doi: 10.1016/j.mbs.2009.10.003. Epub 2009 Oct 23. Math Biosci. 2009. PMID: 19854207
-
Evidence for activation of complement in patients with AIDS related complex (ARC) and/or lymphoadenopathy syndrome (LAS).Clin Exp Immunol. 1987 Dec;70(3):500-7. Clin Exp Immunol. 1987. PMID: 3436097 Free PMC article.
-
Complement in host defense.Scand J Infect Dis Suppl. 1980;Suppl 24:22-9. Scand J Infect Dis Suppl. 1980. PMID: 7010559 Review. No abstract available.
-
The deposition of C5b-9 complexes and its precursors on E. coli J5 during complement activation enhances uptake and toxicities of gentamicin.Immunol Invest. 2008;37(3):245-61. doi: 10.1080/08820130801973682. Immunol Invest. 2008. PMID: 18389443
-
Physiology and pathophysiology of complement: progress and trends.Crit Rev Clin Lab Sci. 1995;32(3):265-98. doi: 10.3109/10408369509084686. Crit Rev Clin Lab Sci. 1995. PMID: 7495498 Review.
Cited by
-
Biomaterials and host versus graft response: a short review.Bosn J Basic Med Sci. 2016 Feb 19;16(2):82-90. doi: 10.17305/bjbms.2016.525. Bosn J Basic Med Sci. 2016. PMID: 26894284 Free PMC article. Review.