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. 2012 Apr 11:10:56.
doi: 10.1186/1477-7819-10-56.

Small bowel involvement is a prognostic factor in colorectal carcinomatosis treated with complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy

Emmanuel I Benizri  1 , Jean-Louis Bernard, Amine Rahili, Daniel Benchimol, Jean-Marc Bereder
Affiliations

Small bowel involvement is a prognostic factor in colorectal carcinomatosis treated with complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy

Emmanuel I Benizri et al. World J Surg Oncol. .

Abstract

Background: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising treatment for patients with peritoneal carcinomatosis (PC). Our objective was to identify new prognostic factors in patients with PC from colorectal cancer treated with this procedure.

Methods: All patients with PC from colorectal cancer treated by HIPEC from January 2000 to December 2007 were prospectively included. The tumor extension was assessed by the Peritoneal Cancer Index (PCI) and the residual disease was recorded using the completeness cytoreductive score (CCs). All clinical and treatment data were computed in univariate and multivariable analyses using survival as primary end point.

Results: We carried out 51 complete procedures in 49 consecutive patients. The mean PCI was 10. The allocation of CCs was: CC-0 = 37, CC-1 = 14. The five-year overall and progression-free survival rate were 40% and 20%, respectively. Several prognostic factors for survival were identified by univariate analysis: PCI < 9 (P < 0.001), CC-0 vs. CC-1 (P < 0.01) and involvement of area 4 (P = 0.06), area 5 (P = 0.031), area 7 (P = 0.014), area 8 (P = 0.022), area 10 (P < 0.0001), and area 11 (P = 0.02). Only the involvement of the distal jejunum (area 10) was significant in the multivariable analysis (P = 0.027).

Conclusions: We demonstrated that the involvement of area 10 (distal jejunum of the PCI score) was an independent factor associated with poor prognosis.

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Figures

Figure 1
Figure 1
Description of the PCI (Peritoneal Cancer Index). The PCI provides an assessment of tumor volume and distribution in the abdominopelvic cavity (nine quadrants) and the small bowel (four regions).
Figure 2
Figure 2
Survival results in 49 patients after HIPEC (hyperthermic intraperitoneal chemotherapy) for colorectal peritoneal carcinomatosis. Overall survival (OS). Disease free survival (DFS).
Figure 3
Figure 3
Kaplan-Meir survival curves for patients with PCI (Peritoneal Cancer Index) > 9 or < 9. In univariate analysis, the PCI is a prognostic factor (Log rank: P < 0.001).
Figure 4
Figure 4
Kaplan-Meir survival curves for patients Cc0 or Cc1 (Cytoreductive score 0 or 1). In univariate analysis, the CCs is a prognostic factor (Log rank: P < 0.01).
See this image and copyright information in PMC

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