Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Apr 12;13(5):315-28.
doi: 10.1038/nrg3187.

Harnessing genomics and genome biology to understand malaria biology

Sarah K Volkman  1 , Daniel E Neafsey, Stephen F Schaffner, Daniel J Park, Dyann F Wirth
Affiliations
Review

Harnessing genomics and genome biology to understand malaria biology

Sarah K Volkman et al. Nat Rev Genet. .

Abstract

Malaria is an important human disease and is the target of a global eradication campaign. New technological and informatics advancements in population genomics are being leveraged to identify genetic loci under selection in the malaria parasite and to find variants that are associated with key clinical phenotypes, such as drug resistance. This article provides a timely Review of how population-genetics-based strategies are being applied to Plasmodium falciparum both to identify genetic loci as key targets of interventions and to develop monitoring and surveillance tools that are crucial for the successful elimination and eradication of malaria.

PubMed Disclaimer

References

    1. Am J Hum Genet. 2010 Feb 12;86(2):172-84 - PubMed
    1. PLoS Pathog. 2009 Oct;5(10):e1000644 - PubMed
    1. Genome Biol. 2011;12(4):R33 - PubMed
    1. Nature. 2008 Oct 9;455(7214):757-63 - PubMed
    1. Proc Natl Acad Sci U S A. 2008 Jun 17;105(24):8393-8 - PubMed

Publication types

LinkOut - more resources