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. 2012 May 24;119(21):e148-50.
doi: 10.1182/blood-2011-10-388702. Epub 2012 Apr 10.

Prediction of cytogenetic abnormalities with gene expression profiles

Yiming Zhou  1 , Qing Zhang, Owen Stephens, Christoph J Heuck, Erming Tian, Jeffrey R Sawyer, Marie-Astrid Cartron-Mizeracki, Pingping Qu, Jason Keller, Joshua Epstein, Bart Barlogie, John D Shaughnessy Jr
Affiliations

Prediction of cytogenetic abnormalities with gene expression profiles

Yiming Zhou et al. Blood. .

Abstract

Cytogenetic abnormalities are important clinical parameters in various types of cancer, including multiple myeloma. We developed a model to predict cytogenetic abnormalities in patients with multiple myeloma using gene expression profiling and validated it by different cytogenetic techniques. The model has an accuracy rate up to 0.89. These results provide proof of concept for the hypothesis that gene expression profiling is a superior genomic method for clinical molecular diagnosis and/or prognosis.

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References

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