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. 2012:2012:639178.
doi: 10.1155/2012/639178. Epub 2012 Feb 1.

Epidemiology, clinical manifestations, and long-term outcomes of a major outbreak of chikungunya in a hamlet in sri lanka, in 2007: a longitudinal cohort study

Senanayake A M Kularatne  1 , Sajitha C Weerasinghe, Champika Gihan, Sujantha Wickramasinghe, Samath Dharmarathne, Asanka Abeyrathna, Thilak Jayalath
Affiliations

Epidemiology, clinical manifestations, and long-term outcomes of a major outbreak of chikungunya in a hamlet in sri lanka, in 2007: a longitudinal cohort study

Senanayake A M Kularatne et al. J Trop Med. 2012.

Abstract

Chikungunya outbreaks occurred in the central province, Sri Lanka in 2006. This community-based study reports the epidemiology and the natural history of the infection from an affected village. Of the 199 families and 1001 individuals in the village, 159 (80%) and 513 (51%) were affected, respectively, comprising 237 (46%) males with peak incidence at 40-50 years. The acute illness caused polyarthritis in 233 (46%), and of them 230 (98%) progressed to chronic arthritic disability (CAD). Of the CAD patients, 102 (44%) had recovered in 141 days (range 30-210 days) from the disability state whilst 128 (56%) had persisting disability which lasted 12, 24, and 36 months in 41 (17.8%), 22 (9.5%), and 14 (6.1%) individuals, respectively. Carpal tunnel syndrome (CTS) manifested in 110 (21%). Females showed preponderance for complications over males: acute arthritis 147 versus 86, P = 0.001; CAD 136 versus 84, P = 0.029; CTS 88 versus 22, P = 0.001; relapses 105 versus 68, P = 0.001. Chikungunya was highly communicable and caused lasting crippling complications.

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Figures

Figure 1
Figure 1
Temporal relationship of chikungunya incidence in Madige.
Figure 2
Figure 2
Relationship between numbers of affected per family and number of individuals per family.
Figure 3
Figure 3
Number of individuals with chronic arthritic disability (CAD) at followup.
See this image and copyright information in PMC

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