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. 2012;7(4):e34952.
doi: 10.1371/journal.pone.0034952. Epub 2012 Apr 4.

Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes

Hirofumi Misu  1 , Kazuhide Ishikura, Seiichiro Kurita, Yumie Takeshita, Tsuguhito Ota, Yoshiro Saito, Kazuhiko Takahashi, Shuichi Kaneko, Toshinari Takamura
Affiliations

Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes

Hirofumi Misu et al. PLoS One. 2012.

Abstract

Background: We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hypoadiponectinemia in patients with type 2 diabetes.

Methodology/principal findings: We compared serum levels of SeP with those of adiponectin and other clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = -0.355, P = 0.034; r = -0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = -0.343, P = 0.022; β = -0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet.

Conclusions/significance: These results suggest that overproduction of liver-derived secretory protein SeP is connected with hypoadiponectinemia in patients with type 2 diabetes.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Correlation between selenoprotein P and glucose concentrations in patients with type 2 diabetes.
Pearson's analysis r and P values are shown.
Figure 2
Figure 2. Correlation between serum levels of selenoprotein P and total adiponectin (A) and high-molecular adiponectin (B) in patients with type 2 diabetes.
Pearson's analysis r and P values are shown.
Figure 3
Figure 3. Blood levels of adiponectin in selenoprotein P-knockout and wild-type mice fed regular chow or a high fat, high sucrose diet (n = 5–10).
Sixteen week old male mice were fed a high fat, high sucrose diet for 16 weeks. Data represents the means ± SEM. *p<0.05, **p<0.01, vs. wild-type mice.
Figure 4
Figure 4. Expression of genes involved in adipogenesis and inflammation in the adipose tissue of selenoprotein P-knockout and wild-type mice fed a high fat, high sucrose diet (n = 5–10).
RNA was isolated from epididymal fat of mice. Data represents the means ± SEM. +p<0.1, *p<0.05, **p<0.01, vs. wild-type mice.
See this image and copyright information in PMC

References

    1. Misu H, Takamura T, Takayama H, Hayashi H, Matsuzawa-Nagata N, et al. A liver-derived secretory protein, selenoprotein P, causes insulin resistance. Cell Metab. 2010;12:483–495. - PubMed
    1. Carlson BA, Novoselov SV, Kumaraswamy E, Lee BJ, Anver MR, et al. Specific excision of the selenocysteine tRNA[Ser]Sec (Trsp) gene in mouse liver demonstrates an essential role of selenoproteins in liver function. J Biol Chem. 2004;279:8011–8017. - PubMed
    1. Hill KE, Zhou J, McMahan WJ, Motley AK, Atkins JF, et al. Deletion of selenoprotein P alters distribution of selenium in the mouse. J Biol Chem. 2003;278:13640–13646. - PubMed
    1. Schomburg L, Schweizer U, Holtmann B, Flohe L, Sendtner M, et al. Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochem J. 2003;370:397–402. - PMC - PubMed
    1. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, et al. Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nat Med. 2002;8:731–737. - PubMed

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