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. 2012 Mar;27(2):108-13.
doi: 10.5001/omj.2012.23.

Estimated Glomerular Filtration Rate (eGFR): A Serum Creatinine-Based Test for the Detection of Chronic Kidney Disease and its Impact on Clinical Practice

Waad-Allah S Mula-Abed, Khalid Al Rasadi, Dawood Al-Riyami

Estimated Glomerular Filtration Rate (eGFR): A Serum Creatinine-Based Test for the Detection of Chronic Kidney Disease and its Impact on Clinical Practice

Waad-Allah S Mula-Abed et al. Oman Med J. 2012 Mar.

Abstract

Chronic kidney disease (CKD) is an important epidemic and public health problem that is associated with a significant risk for vascular disease and early cardiovascular mortality as well as progression of kidney disease. Currently it is classified into five stages based on the glomerular filtration rate (GFR) as recommended by many professional guidelines. Radiolabelled methods for measuring GFR are accurate but not practical and can be used only on a very limited scale while the traditional methods require timed urine collection with its drawback of inaccuracy, cumbersomeness and inconvenience for the patients. However, the development of formula- based calculation of estimated GFR (eGFR) has offered a very practical and easy approach for converting serum creatinine value into GFR result taking into consideration patient's age, sex, ethnicity and weight (depending on equation type). The commonly used equations include Cockraft and Gault (1976), Modification of Diet in Renal Disease (MDRD) (1999) and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) (2009). It is the implementation of these equations particularly the MDRD that has raised the medical awareness in the diagnosis and management of CKD and its adoption by many guidelines in North America and Europe. The impact and pitfalls of each of these equations in the screening, diagnosis and management of patients with CKD are presented and discussed in this review.

Keywords: CKD-EPI; Chronic kidney disease; Cockraft and Gault; MDRD; eGFR.

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References

    1. Astor BC, Matsushita K, Gansevoort RT, van der Velde M, Woodward M, Levey AS, et al. Chronic Kidney Disease Prognosis Consortium Lower estimated glomerular filtration rate and higher albuminuria are associated with mortality and end-stage renal disease. A collaborative meta-analysis of kidney disease population cohorts. Kidney Int 2011. Jun;79(12):1331-1340 10.1038/ki.2010.550 - DOI - PMC - PubMed
    1. National Kidney Foundation K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002. Feb;39(2)(Suppl 1):S1-S266 10.1016/S0272-6386(02)70081-4 - DOI - PubMed
    1. Chronic Kidney Disease: Early identification and management of chronic kidney disease in adults in primary and secondary care. NICE Clinical Guideline 73, September 2008. - PubMed
    1. Stevens PE, O’Donoghue DJ, de Lusignan S, Van Vlymen J, Klebe B, Middleton R, et al. Chronic kidney disease management in the United Kingdom: NEOERICA project results. Kidney Int 2007. Jul;72(1):92-99 10.1038/sj.ki.5002273 - DOI - PubMed
    1. Zhang Q-L, Rothenbacher D. Prevalence of chronic kidney disease in population-based studies: systematic review. BMC Public Health 2008;8:117 10.1186/1471-2458-8-117 - DOI - PMC - PubMed

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