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. 2012 Mar;27(2):124-8.
doi: 10.5001/omj.2012.26.

The Values of CA-125, Progesterone, ß-HCG and Estradiol in the Early Prediction of Ectopic Pregnancy

Meena M Abdul-Hussein, Omar F Abdul-Rasheed, Hala Abdul Qadir Al-Moayed

The Values of CA-125, Progesterone, ß-HCG and Estradiol in the Early Prediction of Ectopic Pregnancy

Meena M Abdul-Hussein et al. Oman Med J. 2012 Mar.

Abstract

Objective: To explore the diagnostic value and measurement of serum CA-125, the single measurement of progesterone (P), ß-HCG, and estradiol (E2) in the early diagnosis of ectopic pregnancy.

Methods: Serum levels of CA-125, progesterone, ß-HCG and estradiol were measured by Enzyme Linked Immuno Sorbent Assay (ELISA) techniques in 40 symptomatic women with ectopic pregnancy and 24 women with normal intrauterine pregnancy during gestational age of 4-10 weeks at Al-Kadhmiya Teaching Hospital, Baghdad, Iraq, between November 2010 and June 2011.

Results: The mean ±SEM serum levels of CA-125, progesterone, ß-HCG, and estradiol in patients with ectopic pregnancies (16.51±2.39U/ml; 2.54±0.47ng/ml; 72.75±12.27mIU/ml; 13.4±2.14pg/ml; respectively) were significantly lower than the levels in normal intrauterine pregnancies (74.25±18.5U/ml; 28.36±3.7ng/ml; 249.54±18.0mIU/ml; 112.7±23.6pg/ml; respectively). When using a CA-125 concentration of 20.5 U/ml as a cut-off value for the diagnosis of ectopic pregnancy, sensitivity was 75.7%, specificity 100%, the positive predictive value was 100% and the negative predictive value 71.4%.

Conclusion: The measurement of CA-125 and progesterone levels is useful in discriminating ectopic from normal gestations.

Keywords: Beta subunit of Human Chorionic Gonadotropin (ß-HCG); Cancer Antigen -125(CA-125); Ectopic pregnancy; Estradiol; Normal intrauterine pregnancy; Progesterone.

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Figures

Figure 1
Figure 1
Receiver Operator Characteristic (ROC) curves of low CA-125 levels as diagnostic tests for ectopic (EP).
Figure 2
Figure 2
Receiver Operator Characteristic (ROC) curves of low progesterone levels as diagnostic tests for ectopic (EP) from control groups.
Figure 3
Figure 3
Receiver Operator Characteristic (ROC) curves of low estradiol levels as diagnostic tests for ectopic (EP) from control groups.
Figure 4
Figure 4
Receiver Operator Characteristic (ROC) curves of low ß-HCG levels as diagnostic tests for ectopic (EP) from control groups.
See this image and copyright information in PMC

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