Genotoxicity studies performed in the ecuadorian population
- PMID: 22496977
- PMCID: PMC3306904
- DOI: 10.1155/2012/598984
Genotoxicity studies performed in the ecuadorian population
Abstract
Genotoxicity studies in Ecuador have been carried out during the past two decades. The focuses of the research were mainly the area of environmental issues, where the populations have been accidentally exposed to contaminants and the area of occupational exposure of individuals at the workplace. This paper includes studies carried out in the population of the Amazon region, a zone known for its rich biodiversity as well as for the ecological damage caused by oil spills and chemical sprayings whose consequences continue to be controversial. Additionally, we show the results of studies comprised of individuals occupationally exposed to toxic agents in two very different settings: flower plantation workers exposed to pesticide mixtures and X-ray exposure of hospital workers. The results from these studies confirm that genotoxicity studies can help evaluate current conditions and prevent further damage in the populations exposed to contaminants. As such, they are evidence of the need for biomonitoring employers at risk, stricter law enforcement regarding the use of pesticides, and increasingly conscientious oil extraction activities.
Similar articles
-
[Environment and health in Gela (Sicily): present knowledge and prospects for future studies].Epidemiol Prev. 2009 May-Jun;33(3 Suppl 1):7-12. Epidemiol Prev. 2009. PMID: 19776462 Italian.
-
Effects of intensive agriculture and urbanization on water quality and pesticide risks in freshwater ecosystems of the Ecuadorian Amazon.Chemosphere. 2023 Oct;337:139286. doi: 10.1016/j.chemosphere.2023.139286. Epub 2023 Jun 26. Chemosphere. 2023. PMID: 37379974
-
Genotoxicity of pesticides: a review of human biomonitoring studies.Mutat Res. 2003 Jun;543(3):251-72. doi: 10.1016/s1383-5742(03)00015-2. Mutat Res. 2003. PMID: 12787816 Review.
-
Cytogenetic monitoring in a population occupationally exposed to pesticides in Ecuador.Environ Health Perspect. 2002 Nov;110(11):1077-80. doi: 10.1289/ehp.110-1241062. Environ Health Perspect. 2002. PMID: 12417477 Free PMC article.
-
The Minderoo-Monaco Commission on Plastics and Human Health.Ann Glob Health. 2023 Mar 21;89(1):23. doi: 10.5334/aogh.4056. eCollection 2023. Ann Glob Health. 2023. PMID: 36969097 Free PMC article. Review.
Cited by
-
De Novo Duplication of Chromosome 9p in a Female Infant: Phenotype and Genotype Correlation.J Pediatr Genet. 2020 Mar;9(1):69-75. doi: 10.1055/s-0039-1696970. Epub 2019 Sep 16. J Pediatr Genet. 2020. PMID: 31976149 Free PMC article.
-
Multi-institutional experience of genetic diagnosis in Ecuador: National registry of chromosome alterations and polymorphisms.Mol Genet Genomic Med. 2020 Feb;8(2):e1087. doi: 10.1002/mgg3.1087. Epub 2019 Dec 12. Mol Genet Genomic Med. 2020. PMID: 31830383 Free PMC article.
-
Polycyclic aromatic hydrocarbon concentrations, mutagenicity, and Microtox® acute toxicity testing of Peruvian crude oil and oil-contaminated water and sediment.Environ Monit Assess. 2014 Apr;186(4):2171-84. doi: 10.1007/s10661-013-3527-2. Epub 2013 Nov 30. Environ Monit Assess. 2014. PMID: 24292871
References
-
- Bohne J, Cathomen T. Genotoxicity in gene therapy: an account of vector integration and designer nucleases. Current Opinion in Molecular Therapeutics. 2008;10(3):214–223. - PubMed
-
- Uhl M, Plewa MJ, Majer BJ, Knasmüller S. Basic principles of genetic toxicology with an emphasis on plant bioassays. In: Maluszynska J, Plewa M, editors. Bioassays in Plant Cells for Improvement of Ecosystem and Human Health. Katowice, Poland; 2003. pp. 11–30.
-
- Westphalen GH, Menezes LM, Prá D, et al. In vivo determination of genotoxicity induced by metals from orthodontic appliances using micronucleus and comet assays. Genetics and Molecular Research. 2008;7(4):1259–1266. - PubMed
-
- Henkler F, Luch A. Adverse health effects of environmental chemical agents through non-genotoxic mechanisms. Journal of Epidemiology and Community Health. 2011;65(1):1–3. - PubMed
-
- Adamus T, Mikulenková I, Dobiáš L, Havránková J, Pek T. Cytogenetic methods and biomonitoring of occupational exposure to genotoxic factors. Journal of Applied Biomedicine. 2006;4(4):197–203.
LinkOut - more resources
Full Text Sources
Research Materials
Miscellaneous