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. 2012:2012:598984.
doi: 10.1155/2012/598984. Epub 2012 Feb 16.

Genotoxicity studies performed in the ecuadorian population

César Paz-Y-Miño  1 , Nadia Cumbal, María Eugenia Sánchez
Affiliations

Genotoxicity studies performed in the ecuadorian population

César Paz-Y-Miño et al. Mol Biol Int. 2012.

Abstract

Genotoxicity studies in Ecuador have been carried out during the past two decades. The focuses of the research were mainly the area of environmental issues, where the populations have been accidentally exposed to contaminants and the area of occupational exposure of individuals at the workplace. This paper includes studies carried out in the population of the Amazon region, a zone known for its rich biodiversity as well as for the ecological damage caused by oil spills and chemical sprayings whose consequences continue to be controversial. Additionally, we show the results of studies comprised of individuals occupationally exposed to toxic agents in two very different settings: flower plantation workers exposed to pesticide mixtures and X-ray exposure of hospital workers. The results from these studies confirm that genotoxicity studies can help evaluate current conditions and prevent further damage in the populations exposed to contaminants. As such, they are evidence of the need for biomonitoring employers at risk, stricter law enforcement regarding the use of pesticides, and increasingly conscientious oil extraction activities.

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References

    1. Bohne J, Cathomen T. Genotoxicity in gene therapy: an account of vector integration and designer nucleases. Current Opinion in Molecular Therapeutics. 2008;10(3):214–223. - PubMed
    1. Uhl M, Plewa MJ, Majer BJ, Knasmüller S. Basic principles of genetic toxicology with an emphasis on plant bioassays. In: Maluszynska J, Plewa M, editors. Bioassays in Plant Cells for Improvement of Ecosystem and Human Health. Katowice, Poland; 2003. pp. 11–30.
    1. Westphalen GH, Menezes LM, Prá D, et al. In vivo determination of genotoxicity induced by metals from orthodontic appliances using micronucleus and comet assays. Genetics and Molecular Research. 2008;7(4):1259–1266. - PubMed
    1. Henkler F, Luch A. Adverse health effects of environmental chemical agents through non-genotoxic mechanisms. Journal of Epidemiology and Community Health. 2011;65(1):1–3. - PubMed
    1. Adamus T, Mikulenková I, Dobiáš L, Havránková J, Pek T. Cytogenetic methods and biomonitoring of occupational exposure to genotoxic factors. Journal of Applied Biomedicine. 2006;4(4):197–203.