Are verbal fluency and nonliteral language comprehension deficits related to depressive symptoms in Parkinson's disease?

Abstract

Depression in Parkinson's disease (PD) is frequently associated with executive deficits, which can influence nonliteral comprehension and lexical access. This study explores whether depressive symptoms in PD modulate verbal fluency and nonliteral language comprehension. Twelve individuals with PD without depressive symptoms, 13 with PD and depressive symptoms (PDDSs), and 13 healthy controls completed a semantic and phonemic verbal fluency task and an indirect speech acts comprehension task. All groups had the same performance in the phonemic fluency task while the PDDS group was impaired in the semantic task. For the indirect speech act comprehension task, no difference was observed between the groups. However, the PDDS group had difficulty answering direct speech act questions. As some language impairments in PD become apparent when depressive symptoms are associated with the disease, it would appear to be important to take the presence of depressive symptoms into account when evaluating language abilities in PD.

Figure 1

Phonemic and semantic verbal fluency mean results (±SEM) for participants with Parkinson's disease with (white column) and without (grey column) depressive symptoms and healthy controls (black column).

Figure 2

Direct and indirect speech act mean results (±SEM) for participants with Parkinson's disease with (white column) and without (grey column) depressive symptoms and healthy controls (black column).