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Editorial
. 2012 Apr 13;110(8):1036-8.
doi: 10.1161/CIRCRESAHA.112.268367.

Neutrophils in atherosclerosis: alarmin evidence of a hit and run?

Daniel I Simon, David Zidar
Editorial

Neutrophils in atherosclerosis: alarmin evidence of a hit and run?

Daniel I Simon et al. Circ Res. .
No abstract available

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Conflict of interest statement

RELATIONSHIPS OF INTEREST

There are no conflicts of interest relating to this manuscript.

Figures

Figure
Figure. The Inflammatory Basis of Atherosclerosis
The progression of atherosclerosis is associated with multiple inter-related immune mechanisms. Proximate signals include a combination of endothelial injury, platelet adhesion and activation, and stimulation of macrophage and T cell responses to modified LDL particles in the intima. The response of the innate immune system may also involve the transient recruitment of neutrophils expressing of alarmins, such as MRP-8/14 and CRAMP. The adaptive immune system includes pro-atherosclerotic responses such as IFN-γ production by CD4+ Th1 lymphocytes as well as protective mechanisms, such as the secretion of neutralizing antibodies by B lymphocytes and the anti-inflammatory activity of regulatory T cells.
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