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Review
. 2012 Feb;32(1):1-11.

A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism

G Cadoni  1 , S Boccia, L Petrelli, P Di Giannantonio, D Arzani, A Giorgio, E De Feo, M Pandolfini, P Gallì, G Paludetti, G Ricciardi
Affiliations
Review

A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism

G Cadoni et al. Acta Otorhinolaryngol Ital. 2012 Feb.

Abstract
in English, Italian

The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).

Lo scopo di questo lavoro è stato valutare la relazione esistente tra i polimorfismi dei geni coinvolti nella carcinogenesi testa- collo, nel metabolismo dell'alcool e nel controllo del ciclo cellulare e il rischio di sviluppare un tumore della testa e del collo (HNC). La revisione è stata effettuata su studi relativi ai polimorfismi genetici e al cancro testa collo (HNC) pubblicati su PubMed fino al settembre 2011. I risultati hanno mostrato l'esistenza di 246 articoli primari e 7 meta-analisi. Tra queste, una associazione statisticamente significativa è stata segnalata per la glutatione S-transferasi (GSTM1), glutatione S-transferasi (GSTT1) e Human microsomal epoxide hydrolase (EPHX1) geni. Un aumentato rischio di sviluppo del tumore testa collo è stato inoltre associato alla presenza della variante di P53 codone 72 Pro/ Pro, di ALDH2, e delle tre varianti del gene ADH: ADH1B (rs1229984), ADH7 (rs1573496) e ADH1C (rs698).

Keywords: Genetic polymorphisms; Genetic susceptibility; Head and neck cancer.

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References

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