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. 2011 Dec;39(4 Suppl):73-81.
doi: 10.2149/tmh.2011-S08. Epub 2011 Oct 12.

Host genetic susceptibility to severe dengue infection

Nguyen Thi Phuong Lan  1 , Kenji Hirayama
Affiliations

Host genetic susceptibility to severe dengue infection

Nguyen Thi Phuong Lan et al. Trop Med Health. 2011 Dec.

Abstract

Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options.

Keywords: HLA; dengue fever; dengue hemorrhagic fever; dengue shock syndrome; genetic susceptibility.

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