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. 2012 May;28(2):273-86.
doi: 10.1016/j.cger.2012.01.007.

Pharmacokinetics and pharmacodynamic changes associated with aging and implications for drug therapy

Leah Church Sera  1 , Mary Lynn McPherson
Affiliations

Pharmacokinetics and pharmacodynamic changes associated with aging and implications for drug therapy

Leah Church Sera et al. Clin Geriatr Med. 2012 May.

Abstract

The population of older adults continues to increase, and polypharmacy in this population is more the rule than the exception. Physiologic changes that occur with aging result in multiple alterations to the pharmacokinetics and pharmacodynamics of drugs, which, in turn, increase the risk of adverse drug reactions. Consideration of initial dose adjustment, along with frequent medication reconciliation and analysis of the medication list, are keys to providing optimal pharmaceutical care for elderly patients.

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