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Comparative Study
. 2012;13(1):91-6.
doi: 10.7314/apjcp.2012.13.1.091.

HPV prevalence and cervical intraepithelial neoplasia among HIV-infected women in Yunnan Province, China: a pilot study

Hong-Yun Zhang  1 , Sarah M Tiggelaar, Vikrant V Sahasrabuddhe, Jennifer S Smith, Cheng-Qin Jiang, Run-Bo Mei, Xian-Guo Wang, Zu-An Li, You-Lin Qiao
Affiliations
Comparative Study

HPV prevalence and cervical intraepithelial neoplasia among HIV-infected women in Yunnan Province, China: a pilot study

Hong-Yun Zhang et al. Asian Pac J Cancer Prev. 2012.

Abstract

Objectives: To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China.

Methods: Cervical cytology, HPV detection by Hybrid Capture-2™ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters.

Results: Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with <CIN1 after adjusting for age (OR: 8.3, 95% CI: 0.9, 73.4). Women with CD4+ cell counts less than 350 cells/μL had higher CIN2+ prevalence after adjusting for current ART status and age (adjusted OR: 6.3, 95% CI: 1.1, 36.5).

Conclusions: HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.

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Figures

Figure 1
Figure 1
Sensitivity and Specificity for CIN2+ of HPV DNA (Hybrid Capture 2) Testing vs. Cytology among HIV-infected women in Yunnan, China
See this image and copyright information in PMC

References

    1. Akinwuntan AL, Adesina OA, Okolo CA, et al. Correlation of cervical cytology and visual inspection with acetic acid in HIV-positive women. J Obstet Gynaecol. 2008;28:638–41. - PubMed
    1. Belinson JL, Qiao YL, Pretorius RG, et al. Shanxi Province cervical cancer screening study II: self-sampling for high-risk human papillomavirus compared to direct sampling for human papillomavirus and liquid based cervical cytology. Int J Gynecol Cancer. 2003;13:819–26. - PubMed
    1. de Andrade AC, Luz PM, Velasque L, et al. Factors associated with colposcopy-histopathology confirmed cervical intraepithelial neoplasia among HIV-infected women from Rio De Janeiro, Brazil. PLoS One. 2011;6:e18297. - PMC - PubMed
    1. Denny L, Boa R, Williamson AL, et al. Human papillomavirus infection and cervical disease in human immunodeficiency virus-1-infected women. Obstet Gynecol. 2008;111:1380–7. - PubMed
    1. Dexeus S, Cararach M, Dexeus D. The role of colposcopy in modern gynecology. Eur J Gynaecol Oncol. 2002;23:269–77. - PubMed

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