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. 2011 Dec 28;52(52):7091-7094.
doi: 10.1016/j.tetlet.2011.10.090.

Investigation of copper(II) tetrafluoroborate catalysed epoxide opening

Amy S Capes  1 , Arthur T Crossman, Lauren A Webster, Michael A J Ferguson, Ian H Gilbert
Affiliations

Investigation of copper(II) tetrafluoroborate catalysed epoxide opening

Amy S Capes et al. Tetrahedron Lett. .

Abstract

We report the extension of the copper(II) tetrafluoroborate catalysed opening of epoxides with alcohols to include a wider variety of alcohols, a range of solvents and a method to purify the products from the reaction.

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Figures

None
Graphical abstract
Scheme 1
Scheme 1
General reaction for copper(II) tetrafluoroborate catalysed epoxide opening.
Scheme 2
Scheme 2
Copper(II) tetrafluoroborate catalysed epoxide opening solvent study.
Scheme 3
Scheme 3
Transition state for the copper(II) tetrafluoroborate catalysed opening of cyclohexene oxide.
Scheme 4
Scheme 4
Example of the trityl chloride method for removing excess alcohol.
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