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Review
. 2012 Jan-Mar;25(1):31-8.
doi: 10.1177/039463201202500105.

IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation

S Tete, D Tripodi, M Rosati, F Conti, G Maccauro, A Saggini, E Cianchetti, A Caraffa, P Antinolfi, E Toniato, M L Castellani, P Conti, T C Theoharides
Free article
Review

IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation

S Tete et al. Int J Immunopathol Pharmacol. 2012 Jan-Mar.
Free article

Abstract

Cytokines such as interleukins, chemokines and interferons are immunomodulating and inflammatory agents, characterized by considerable redundancy, in that many cytokines appear to share similar functions. Virtually all nucleated cells, but especially epithelial cells and macrophages, are potent producers of cytokines. The objective of this study is to review the detailed mechanism of action and the biological profiles of IL-37, the newest anti-inflammatory cytokine. This review focuses on IL-37, a key cytokine in regulating inflammatory responses, mainly by inhibiting the expression, production and function of proinflammatory cytokines: IL-1 family pro-inflammatory effects are markedly suppressed by IL-37.

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