Metabolic properties of hormonally responsive osteogenic sarcoma cells

Abstract

There is sufficient impetus from the clinical nature of osteogenic sarcoma to stimulate basic studies of the effects of hormones on tumor growth and differentiation. This can probably best be done first by the use of in vitro studies to determine precisely the effects of certain hormones on tumor cell growth and biochemical function. Such investigations would hopefully indicate the direction of in vivo work. The differentiated transplantable tumor described in this paper is clearly hormone-responsive, and offers a means of investigating the effects of other hormones, including growth hormone, androgens, estrogens and glucocorticoids, on specialized function of the osteogenic sarcoma cells, and on the growth of the tumor.