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Review
. 2012 Apr 15;27(5):597-607.
doi: 10.1002/mds.24921.

Lewy pathology and neurodegeneration in premotor Parkinson's disease

Kelly Del Tredici  1 , Heiko Braak
Affiliations
Review

Lewy pathology and neurodegeneration in premotor Parkinson's disease

Kelly Del Tredici et al. Mov Disord. .

Abstract

The foremost motor manifestations of Parkinson's disease are resting tremor, cogwheel rigidity, hypokinesia/bradykinesia, and postural instability. Epidemiological and clinical data reveal that a wide variety of additional complaints (nonmotor symptoms), also considerably impar patients' quality of life parallel to the chronic-progressive neurodegenerative disorder. This article reviews the neuropathology and anatomy of Lewy pathology-related neurodegeneration in relation to selected nonmotro and prodromal dysfunctions.

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