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Review
. 2012 Apr 15;27(5):644-50.
doi: 10.1002/mds.24956.

Biochemical premotor biomarkers for Parkinson's disease

Brit Mollenhauer  1 , Jing Zhang
Affiliations
Review

Biochemical premotor biomarkers for Parkinson's disease

Brit Mollenhauer et al. Mov Disord. .

Abstract

A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We reviewed the current status of target protein biomarkers (eg, total/oligomeric α-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We have also provide details about strategies toward potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the premotor stage of Parkinson's disease in the future.

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