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Comment

. 2012 Apr 17;109(16):5913-4.

doi: 10.1073/pnas.1203764109. Epub 2012 Apr 16.

Rethinking the purinergic neuron-glia connection

Bertil B Fredholm¹

Affiliations

PMID: 22509008
PMCID: PMC3340997
DOI: 10.1073/pnas.1203764109

Comment

Rethinking the purinergic neuron-glia connection

Bertil B Fredholm. Proc Natl Acad Sci U S A. 2012.

. 2012 Apr 17;109(16):5913-4.

doi: 10.1073/pnas.1203764109. Epub 2012 Apr 16.

Author

Bertil B Fredholm¹

Affiliation

¹ Department of Physiology and Pharmacology, Karolinska Institutet, S-171 77 Stockholm, Sweden. bertil.fredholm@fyfa.ki.se

PMID: 22509008
PMCID: PMC3340997
DOI: 10.1073/pnas.1203764109

No abstract available

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Conflict of interest statement

The author declares no conflict of interest.

Comment on

Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity.
Lovatt D, Xu Q, Liu W, Takano T, Smith NA, Schnermann J, Tieu K, Nedergaard M. Lovatt D, et al. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6265-70. doi: 10.1073/pnas.1120997109. Epub 2012 Mar 15. Proc Natl Acad Sci U S A. 2012. PMID: 22421436 Free PMC article.

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References

1. Johansson B, et al. Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A1 receptor. Proc Natl Acad Sci USA. 2001;98:9407–9412. - PMC - PubMed
1. Dunwiddie TV. Endogenously released adenosine regulates excitability in the in vitro hippocampus. Epilepsia. 1980;21:541–548. - PubMed
1. Fedele DE, Li T, Lan JQ, Fredholm BB, Boison D. Adenosine A1 receptors are crucial in keeping an epileptic focus localized. Exp Neurol. 2006;200:184–190. - PubMed
1. Lovatt D, et al. Neuronal adenosine release, and not astrocytic ATP release, mediates feedback inhibition of excitatory activity. Proc Natl Acad Sci USA. 2012;109:6265–6270. - PMC - PubMed
1. Fredholm BB, Hedqvist P. Modulation of neurotransmission by purine nucleotides and nucleosides. Biochem Pharmacol. 1980;29:1635–1643. - PubMed

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