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. 2012 May 4;14(9):2394-7.
doi: 10.1021/ol300813c. Epub 2012 Apr 17.

Direct palladium(II)-catalyzed synthesis of arylamidines from aryltrifluoroborates

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Free PMC article

Direct palladium(II)-catalyzed synthesis of arylamidines from aryltrifluoroborates

Jonas Sävmarker et al. Org Lett. .
Free PMC article

Abstract

A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 20 min microwave protocol using Pd(O(2)CCF(3)), 6-methyl-2,2'-bipyridyl, TFA, and MeOH, providing the corresponding arylamidines in moderate to excellent yields.

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Figures

Figure 1
Figure 1
Proposed catalytic cycle.

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