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Comment
. 2012 Apr 17;3(2):e00082-12.
doi: 10.1128/mBio.00082-12. Print 2012.

Human origin for livestock-associated methicillin-resistant Staphylococcus aureus

J Ross Fitzgerald  1
Affiliations
Comment

Human origin for livestock-associated methicillin-resistant Staphylococcus aureus

J Ross Fitzgerald. mBio. .

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of human morbidity and mortality worldwide. The emergence in the last decade of a livestock-associated MRSA (LA-MRSA) clone which also has the capacity to cause zoonotic infections in humans has raised important questions regarding its origin and its potential to cause human epidemics. An important study by L. B. Price et al. [mBio 3(1):e00305-11, 2012] provides evidence for a human ancestral origin for LA-MRSA, raising concerns about agricultural practices that may have contributed to its emergence and expansion. The study highlights the potential for comparative whole-genome sequencing of closely related strains to provide valuable insights into the evolutionary history of bacterial pathogens.

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Figures

FIG 1
FIG 1
A livestock market in Saqisili, Ecuador, in August 2010. Printed with permission by Pierre Jean Durieu.
See this image and copyright information in PMC

Comment on

  • Staphylococcus aureus CC398: host adaptation and emergence of methicillin resistance in livestock.
    Price LB, Stegger M, Hasman H, Aziz M, Larsen J, Andersen PS, Pearson T, Waters AE, Foster JT, Schupp J, Gillece J, Driebe E, Liu CM, Springer B, Zdovc I, Battisti A, Franco A, Zmudzki J, Schwarz S, Butaye P, Jouy E, Pomba C, Porrero MC, Ruimy R, Smith TC, Robinson DA, Weese JS, Arriola CS, Yu F, Laurent F, Keim P, Skov R, Aarestrup FM. Price LB, et al. mBio. 2012 Feb 21;3(1):e00305-11. doi: 10.1128/mBio.00305-11. Print 2012. mBio. 2012. PMID: 22354957 Free PMC article.

References

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