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. 2012 Oct;97(10):1603-7.
doi: 10.3324/haematol.2012.064444. Epub 2012 Apr 17.

Thrombosis is associated with inferior survival in multiple myeloma

Sigurdur Y Kristinsson  1 , Ruth M Pfeiffer, Magnus Björkholm, Sam Schulman, Ola Landgren
Affiliations

Thrombosis is associated with inferior survival in multiple myeloma

Sigurdur Y Kristinsson et al. Haematologica. 2012 Oct.

Abstract

Patients with multiple myeloma are at an increased risk of venous thromboembolism and arterial thrombosis. We assessed the impact of venous and arterial thrombosis on survival in a population-based study of 9,399 multiple myeloma patients diagnosed in Sweden from 1987 to 2005. We found multiple myeloma patients with venous thromboembolism to have a higher mortality at 1-, 5-, and 10-years of follow up compared with those without, with hazard ratios of 2.9 (95% confidence interval (CI) 2.4-3.5), 1.6 (95% CI: 1.5-1.8), and 1.6 (95% CI: 1.4-1.7), respectively. There was an increase in risk of death among multiple myeloma patients with arterial thrombosis, with hazard ratios of 3.4 (95% CI: 3.0-3.8), 2.2 (95% CI: 2.0-2.3), and 2.1 (95% CI: 1.9-2.1), respectively. In landmark analyses at six months, early arterial but not venous thromboembolism was associated with a higher risk of death. Thus, in contrast to prior smaller studies, we found the development of thrombosis to be associated with significantly poorer survival. The prevention of thrombosis in multiple myeloma is an important goal in the management of these patients.

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Figures

Figure 1.
Figure 1.
Survival among multiple myeloma patients with and without early venous thrombembolism (landmark analysis).
Figure 2.
Figure 2.
Survival among multiple myeloma patients with and without early arterial thrombosis (landmark analysis).
See this image and copyright information in PMC

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