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. 1990 Dec;87(23):9411-5.
doi: 10.1073/pnas.87.23.9411.

Expression and chromosomal localization of a lymphocyte K+ channel gene

S Grissmer  1 , B Dethlefs, J J Wasmuth, A L Goldin, G A Gutman, M D Cahalan, K G Chandy
Affiliations

Expression and chromosomal localization of a lymphocyte K+ channel gene

S Grissmer et al. Proc Natl Acad Sci U S A. 1990 Dec.

Abstract

We recently isolated a family of three closely related mouse K+ channel genes (MK1, MK2, and MK3) with coding regions contained in single uninterrupted exons. Here we have used patch-clamp recordings from Xenopus oocytes injected with mRNA to show that MK3 encodes a channel with biophysical and pharmacological properties indistinguishable from those of voltage-gated type n K+ channels in T cells. In addition, we used the polymerase chain reaction to demonstrate the presence of MK3 mRNA in T cells. These data suggest that MK3 may encode the T-cell voltage-gated type n K+ channel. We also show that MK3 and MK2 are localized on human chromosomes 13 and 12, respectively.

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References

    1. Science. 1990 Feb 23;247(4945):973-5 - PubMed
    1. EMBO J. 1989 Nov;8(11):3235-44 - PubMed
    1. EMBO J. 1990 Mar;9(3):777-82 - PubMed
    1. Nature. 1990 Jun 7;345(6275):530-4 - PubMed
    1. Nature. 1990 Jun 7;345(6275):535-7 - PubMed

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