Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Dec;18(12):1791-6.
doi: 10.1177/1352458512445943. Epub 2012 Apr 18.

No association between chronic cerebrospinal venous insufficiency and pediatric-onset multiple sclerosis

M P Amato  1 , V Saia, B Hakiki, M Giannini, L Pastò, S Zecchino, S Lori, E Portaccio, M Marinoni
Affiliations

No association between chronic cerebrospinal venous insufficiency and pediatric-onset multiple sclerosis

M P Amato et al. Mult Scler. 2012 Dec.

Abstract

Objective: Chronic cerebrospinal venous insufficiency (CCSVI) was hypothesized to play a causative role in multiple sclerosis (MS). The assessment of pediatric-onset MS (POMS) may provide a unique window of opportunity to study hypothesized risk factors in close temporal association with the onset of the disease.

Methods: Internal jugular veins, vertebral veins and intracranial veins were evaluated with extracranial and intracranial ultrasound in 15 POMS and 16 healthy controls. Assessor's blinding was maintained during the study. We considered subjects positive to CCSVI when at least two criteria were fulfilled.

Results: CCSVI frequency was comparable between POMS and controls (p > 0.05). Clinical features were not significantly different between CCSVI-positive and CCSVI-negative patients.

Conclusions: Our findings add to previous data pointing against a causative role of CCSVI in MS.

PubMed Disclaimer

Publication types

LinkOut - more resources