Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 Jun;14(6):768-76.
doi: 10.1093/neuonc/nos078. Epub 2012 Apr 18.

Outcomes of hospitalization in pregnant women with CNS neoplasms: a population-based study

Anna R Terry  1 , Fred G Barker 2nd, Lisa Leffert, Brian T Bateman, Irene Souter, Scott R Plotkin
Affiliations

Outcomes of hospitalization in pregnant women with CNS neoplasms: a population-based study

Anna R Terry et al. Neuro Oncol. 2012 Jun.

Abstract

Managing a CNS neoplasm during pregnancy presents complex challenges, and population-based studies are lacking. We designed a retrospective cohort study using the Nationwide Inpatient Sample (NIS) to investigate pregnancy outcomes in women with CNS neoplasms. We constructed a logistic regression model for maternal mortality, preterm labor, intrauterine growth restriction (IUGR), and Caesarean delivery, controlling for age, comorbidities, and demographic characteristics. We identified 379 malignant brain tumors, 437 benign brain tumors, and 44 spine tumors among 19 million pregnancy-related admissions from 1988 through 2009. Malignant brain tumors were associated with maternal mortality (odds ratio [OR], 143), preterm labor (OR, 3.4), and IUGR (OR, 2.9). Benign brain tumors were associated with preterm labor (OR, 2.3). A diagnosis of hyperemesis gravidarum was more common in malignant (OR, 2.2) and benign (OR, 2.8) brain tumors. Compared with the general population, Caesarean delivery was more frequent for malignant (OR, 6.4) and benign (OR, 2.8) brain tumors and spine tumors (OR, 3.9). Admission without delivery was more common for malignant (OR, 8.6) and benign (OR, 4.3) brain tumors and spine tumors (OR, 3.8; P < .05 for all outcomes). Thirty-three percent of all hospitalizations involved neurosurgical procedures, but pregnancy complications were not significantly more likely to occur in surgical patients. In conclusion, malignant brain tumors were associated with adverse pregnancy outcomes, and CNS neoplasms were associated with higher rates of Caesarean delivery. Additional research is needed to improve understanding of obstetric risk in these patients and to assist with treatment, counseling, and monitoring during delivery.

PubMed Disclaimer

Figures

Fig. 1.
Fig. 1.
Trend in US Caesarean delivery rate for brain tumors and the general population, 1988–2009.
See this image and copyright information in PMC

References

    1. Stevenson CB, Thompson RC. The clinical management of intracranial neoplasms in pregnancy. Clin Obstet Gynecol. 2005;48(1):24–37. doi:10.1097/01.grf.0000153209.70749.d0. - DOI - PubMed
    1. CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2004–2007. February 2011. - PubMed
    1. Roelvink NC, Kamphorst W, van Alphen HA, Rao BR. Pregnancy-related primary brain and spinal tumors. Arch Neurol. 1987;44(2):209–215. doi:10.1001/archneur.1987.00520140069020. - DOI - PubMed
    1. Haas JF, Janisch W, Staneczek W. Newly diagnosed primary intracranial neoplasms in pregnant women: a population-based assessment. J Neurol Neurosurg Psychiatry. 1986;49(8):874–880. doi:10.1136/jnnp.49.8.874. - DOI - PMC - PubMed
    1. Cowppli-Bony A, Bouvier G, Rue M, et al. Brain tumors and hormonal factors: review of the epidemiological literature. Cancer Causes Control. 2011;22(5):697–714. doi:10.1007/s10552-011-9742-7. - DOI - PubMed

Publication types

MeSH terms