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Review
. 2011 Nov 14;4(4):320-3.
Epub 2011 Nov 24.

Minimally invasive treatment for female stress urinary incontinence - Romanian highlights

C Surcel  1 , C Chibelean, A Iordache, C Mirvald, C Gîngu, S Margaritis, R Stoica, C Codoiu, C Savu, R Marksteiner, I Sinescu
Affiliations
Review

Minimally invasive treatment for female stress urinary incontinence - Romanian highlights

C Surcel et al. J Med Life. .

Retraction in

  • Retractions.
    [No authors listed] [No authors listed] J Med Life. 2012 Jun 12;5(2):246-7. Epub 2012 Jun 18. J Med Life. 2012. PMID: 22802902 Free PMC article. No abstract available.

Abstract

Rationale: Stress urinary incontinence is still a "battlefield" for many minimally invasive therapies, but, unfortunately, few can restore the anatomical and functional background of this disorder.

Objective: Assessing the latest minimally invasive procedures of intra and perisphincterian injection of autologous stem cells.

Method and result: The first stem cell implantation (myoblasts and /or mature fibroblasts grown and multiplied in the laboratory from biopsy samples taken from the pectoralis muscle) in the urethral sphincter was performed on October 18, 2010, in "Fundeni" Clinic of Urology and Renal Transplantation, in Romania.

Discussion: The follow-up at six weeks with the quality of life questionnaires, micturition diary and clinical examination revealed a decrease of urine loss from six pads/ day at one per day, which significantly improved the patient's quality of life according to visual analogue scale. Clinical and urodynamic evaluations will continue and will be future scientific topics.

Keywords: myoblasts; stem cells; transplantation; urethral sphincter.

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Figures

Fig. 1
Fig. 1
Theoretical scheme of stem cells implantation (with the permission of Prof. Marksteiner)
Fig. 2
Fig. 2
Myoblast growth in cell culture –200x, antiDesmine staining (With permission from Prof. Marksteiner).
Fig. 3
Fig. 3
Myoblasts fusion to the myotubuli in cell culture –200x, antiDesmnine staining (with permission from Prof. Marksteiner).
Fig. 4
Fig. 4
Urethral sphincter ultrasound - intraoperative aspect
See this image and copyright information in PMC

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