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. 2012;7(4):e34218.
doi: 10.1371/journal.pone.0034218. Epub 2012 Apr 13.

Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study

Jeffrey K Lee  1 , Ricki Bettencourt, David Brenner, Thuy-Anh Le, Elizabeth Barrett-Connor, Rohit Loomba
Affiliations

Association between serum interleukin-6 concentrations and mortality in older adults: the Rancho Bernardo study

Jeffrey K Lee et al. PLoS One. 2012.

Abstract

Background: Interleukin-6 (IL-6) may have a protective role in acute liver disease but a detrimental effect in chronic liver disease. It is unknown whether IL-6 is associated with risk of liver-related mortality in humans.

Aims: To determine if IL-6 is associated with an increased risk of all-cause, cardiovascular disease (CVD), cancer, and liver-related mortality.

Methods: A prospective cohort study included 1843 participants who attended a research visit in 1984-87. Multiple covariates were ascertained including serum IL-6. Multivariable-adjusted Cox proportional hazards regression analyses were used to examine the association between serum IL-6 as a continuous (log transformed) variable with all-cause, CVD, cancer, and liver-related mortality. Patients with prevalent CVD, cancer and liver disease were excluded for cause-specific mortality.

Results: The mean (± standard deviation) age and body-mass-index (BMI) of participants was 68 (± 10.6) years and 25 (± 3.7) Kg/m(2), respectively. During the 25,802 person-years of follow-up, the cumulative all-cause, CVD, cancer, and liver-related mortality were 53.1% (N = 978), 25.5%, 11.3%, and 1.3%, respectively. The median (± IQR) length of follow-up was 15.3 ± 10.6 years. In multivariable analyses, adjusted for age, sex, alcohol, BMI, diabetes, hypertension, total cholesterol, HDL, and smoking, one-SD increment in log-transformed serum IL-6 was associated with increased risk of all-cause, CVD, cancer, and liver-related mortality, with hazard ratios of 1.48 (95% CI, 1.33-1.64), 1.38 (95% CI, 1.16-1.65), 1.35 (95% CI, 1.02-1.79), and 1.88 (95% CI, 0.97-3.67), respectively. CRP adjustment attenuated the effects but the association between IL-6 and all-cause and CVD mortality remained statistically significant, independent of CRP levels.

Conclusions: In community-dwelling older adults, serum IL-6 is associated with all-cause, CVD, cancer, and liver-related mortality.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

References

    1. Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med; 1998;128(2):127–137. - PubMed
    1. Kovalovich K, Li W, DeAngelis R, Greenbaum LE, Ciliberto G, et al. Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL. J Biol Chem; 2001;276(28):26605–26613. - PubMed
    1. Jin X, Zimmers TA, Perez EA, Pierce RH, Zhang Z, et al. Paradoxical effects of short- and long-term interleukin-6 exposure on liver injury and repair. Hepatology; 2006;43(3):474–484. - PubMed
    1. Maggio M, Guralnik JM, Longo DL, Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci; 2006;61(6):575–584. - PMC - PubMed
    1. Pai JK, Pischon T, Ma J, Manson JE, Hankinson SE, et al. Inflammatory markers and the risk of coronary heart disease in men and women. N Engl J Med; 2004;351(25):2599–2610. - PubMed

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