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Review
. 2013 Apr;19(2):182-200.
doi: 10.1080/13554794.2011.654227. Epub 2012 Apr 19.

Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship

Brianne Magouirk Bettcher  1 , Joel H Kramer
Affiliations
Review

Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship

Brianne Magouirk Bettcher et al. Neurocase. 2013 Apr.

Abstract

A proposed immune mechanism that potentially modifies or exacerbates neurodegenerative disease presentation in older adults has received considerable attention in the past decade, with recent studies demonstrating a strong link between pro-inflammatory markers and neurodegeneration. The overarching aim of the following review is to synthesize recent research that supports a possible relationship between inflammation and clinical features of neurodegenerative diseases, including risk of development, cognitive and clinical correlates, and progression of the specified diseases. Specific emphasis is placed on providing a temporal context for the association between inflammation and neurodegeneration.

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Figures

Figure 1
Figure 1
Temporal course of inflammation in neurodegenerative disease, within the context of possible points of impact. Inflammation may play a precipitating (A), contributory (B), or reactionary (C) role in the disease process.
See this image and copyright information in PMC

References

    1. Alley DE, Crimmins EM, Karlamangla A, Hu P, Seeman TE. Inflammation and rate of cognitive change in high-functioning older adults. Journal of Gerontology Series A: Biological Sciences and Medical Sciences. 2008;63:50–55. - PMC - PubMed
    1. Anan F, Masaki T, Shimomura T, Fujiki M, Umeno Y, Eshima N, Saikawa T, Yoshimatsu H. High-sensitivity C-reactive protein is associated with hippocampus volume in nondementia patients with type 2 diabetes mellitus. Metabolism. 2011;60:460–466. - PubMed
    1. Arends YM, Duyckaerts C, Rozemuller JM, Eikelenboom P, Hauw JJ. Microglia, amyloid and dementia in alzheimer disease. A correlative study. Neurobiology of Aging. 2000;21:39–47. - PubMed
    1. Arvanitakis Z, Grodstein F, Bienias JL, Schneider JA, Wilson RS, Kelly JF, Evans DA, Bennett DA. Relation of NSAIDs to incident AD, change in cognitive function, and AD pathology. Neurology. 2008;70:2219–2225. - PubMed
    1. Baker M, Mackenzie IR, Pickering-Brown SM, Gass J, Rademakers R, Lindholm C, Snowden J, Adamson J, Sadovnick AD, Rollinson S, et al. Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17. Nature. 2006;442:916–919. - PubMed

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