Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2012 May;18(5):869-72.
doi: 10.3201/eid1805.111712.

Hepatitis E virus infection among solid organ transplant recipients, the Netherlands

Suzan D Pas  1 , Rob A de Man, Claudia Mulders, Aggie H M M Balk, Peter T W van Hal, Willem Weimar, Marion P G Koopmans, Albert D M E Osterhaus, Annemiek A van der Eijk
Affiliations

Hepatitis E virus infection among solid organ transplant recipients, the Netherlands

Suzan D Pas et al. Emerg Infect Dis. 2012 May.

Abstract

We screened 1,200 living heart, lung, liver, and kidney transplant recipients for hepatitis E virus infection by reverse transcription PCR. In 12 (1%) patients, hepatitis E virus infection was identified; in 11 patients, chronic infection developed. This immunocompromised population is at risk for hepatitis E virus infection.

PubMed Disclaimer

Figures

Figure
Figure
Phylogenetic tree of hepatitis E virus (HEV) open reading frame (ORF) 1 sequences, including HEV infections, the Netherlands, 2000–2011. Phylogenetic relation of a 306-bp ORF1 region was calculated by using maximum-likelihood, Kimura 2-parameter analysis with bootstrapping (n = 1,000). HEV sequences originating in the Netherlands are indicated as NL with year of isolation and isolate number (GenBank accession nos. JQ015399–JQ015448). Boldface indicates virus strains of chronic HEV-infected solid organ transplant recipients identified in this study. Scale bar indicates number of nucleotide substitutions per site. HTX, heart transplant; NTX, kidney transplant; LTX, liver transplant; lungTX, lung transplant.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Tavitian S, Peron JM, Huynh A, Mansuy JM, Ysebaert L, Huguet F, et al. Hepatitis E virus excretion can be prolonged in patients with hematological malignancies. J Clin Virol. 2010;49:141–4. 10.1016/j.jcv.2010.06.016 - DOI - PubMed
    1. Sellier P, Mazeron MC, Tesse S, Badsi E, Evans J, Magnier JD, et al. Hepatitis E virus infection in HIV-infected patients with elevated serum transaminases levels. Virol J. 2011;8:171. 10.1186/1743-422X-8-171 - DOI - PMC - PubMed
    1. Borgen K, Herremans T, Duizer E, Vennema H, Rutjes S, Bosman A, et al. Non-travel related hepatitis E virus genotype 3 infections in the Netherlands; a case series 2004–2006. BMC Infect Dis. 2008;8:61. 10.1186/1471-2334-8-61 - DOI - PMC - PubMed
    1. Schlosser B, Stein A, Neuhaus R, Pahl S, Ramez B, Kruger DH, et al. Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient. J Hepatol. 2012;56:500–2. Epub 2011 Jul 26. 10.1016/j.jhep.2011.06.021 - DOI - PubMed
    1. Zhao C, Li Z, Yan B, Harrison TJ, Guo X, Zhang F, et al. Comparison of real-time fluorescent RT-PCR and conventional RT-PCR for the detection of hepatitis E virus genotypes prevalent in China. J Med Virol. 2007;79:1966–73. 10.1002/jmv.21040 - DOI - PubMed

Publication types

Associated data

LinkOut - more resources