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. 1990 Oct;106(1):48-52.
doi: 10.1016/0041-008x(90)90104-3.

Atropine inhibition of the cardiodepressive effect of mono(2-ethylhexyl)phthalate on human myocardium

Y A Barry  1 , R S Labow, W J Keon, M Tocchi
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Atropine inhibition of the cardiodepressive effect of mono(2-ethylhexyl)phthalate on human myocardium

Y A Barry et al. Toxicol Appl Pharmacol. 1990 Oct.

Abstract

Di(2-ethylhexyl)phthalate (DEHP) is a commonly used plasticizer in polyvinylchloride (PVC)-derived plastic. Mono(2-ethylhexyl)phthalate (MEHP), the major metabolite of DEHP, had a reversible, concentration-dependent (15-200 micrograms/ml) negative inotropic effect on a human in vitro atrial trabecular isometric preparation with an IC50 of 85 micrograms/ml. When atropine (22-32 micrograms/ml) was included in the atrial preparation the IC50 was shifted to greater than 120 micrograms/ml, suggesting that MEHP acts in part through the cholinergic receptors.

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