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. 2012:2012:652682.
doi: 10.5402/2012/652682. Epub 2012 Feb 16.

Prognostic Biomarkers and EBV Infection Research in Diffuse Large B-Cell Lymphoma of the Palatine Tonsils

Marinho Marques  1 , Estela Luz, Michael Hummel, Maria das Graças Vieira, Regina Célia Bahia, Maria Cristina Oliveira, Eduardo Martins Netto, Ivana Luz, Iguaracyra Araújo
Affiliations

Prognostic Biomarkers and EBV Infection Research in Diffuse Large B-Cell Lymphoma of the Palatine Tonsils

Marinho Marques et al. ISRN Oncol. 2012.

Abstract

Diffuse large B-cell lymphoma represents approximately 30%-40% of all diagnoses of non-Hodgkin's Lymphoma and may represent up to 80% of all lymphomas that arise in the palatine tonsils. Several studies have attempted to correlate clinical, laboratorial, and tissue factors with the prognosis of the lymphomas, such as the International Prognostic Index, the tissue expression of some proteins, and the lymphocyte count at the time of diagnosis, as well as to correlate Epstein-Barr virus (EBV) infection with worse prognoses. Patients with palatine tonsil DLBCL, from Salvador, Bahia, Brazil, were studied in order to identify prognostic factors. Twenty-four patients with DLBCL were studied. The factors that negatively influenced the patients' survival rates were the lymphocyte count at the time of diagnosis <1.000/mm(3) and the Bcl-2 protein expression. There was no CD5 expression in these lymphomas, and neither was there an association with EBV infection.

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Figures

Figure 1
Figure 1
Overall survival and event-free survival considering lymphocyte count at the time of diagnosis.
Figure 2
Figure 2
Immunohistochemical aspects of the palatine tonsils DLBCL: positivity for CD10 (a), Bcl-6 (b), MUM-1 (c), and Bcl-2 (d) antibodies.
Figure 3
Figure 3
Overall survival and event-free survival considering Bcl-2 protein status at the time of diagnosis.
See this image and copyright information in PMC

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