Shigella navigates tight corners
- PMID: 22520458
- DOI: 10.1016/j.chom.2012.04.001
Shigella navigates tight corners
Abstract
In this issue, Fukumatsu and colleagues (2012) find that Shigella preferentially spread from cell-to-cell at unique intercellular junctions. Shigella protrusions invade adjacent cells at junctions where three cells meet, the tricellular junction. The tight junction protein tricellulin marks these sites and is important for Shigella spread.
Copyright © 2012 Elsevier Inc. All rights reserved.
Comment on
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Shigella targets epithelial tricellular junctions and uses a noncanonical clathrin-dependent endocytic pathway to spread between cells.Cell Host Microbe. 2012 Apr 19;11(4):325-36. doi: 10.1016/j.chom.2012.03.001. Cell Host Microbe. 2012. PMID: 22520461
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