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. 2012 Oct 15;72(8):707-9.
doi: 10.1016/j.biopsych.2012.03.011. Epub 2012 Apr 19.

Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms

Gitta H Lubke  1 , Jouke Jan Hottenga, Raymond Walters, Charles Laurin, Eco J C de Geus, Gonneke Willemsen, Jan H Smit, Christel M Middeldorp, Brenda W J H Penninx, Jacqueline M Vink, Dorret I Boomsma
Affiliations

Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms

Gitta H Lubke et al. Biol Psychiatry. .

Abstract

Genome-wide association studies of psychiatric disorders have been criticized for their lack of explaining a considerable proportion of the heritability established in twin and family studies. Genome-wide association studies of major depressive disorder in particular have so far been unsuccessful in detecting genome-wide significant single nucleotide polymorphisms (SNPs). Using two recently proposed methods designed to estimate the heritability of a phenotype that is attributable to genome-wide SNPs, we show that SNPs on current platforms contain substantial information concerning the additive genetic variance of major depressive disorder. To assess the consistency of these two methods, we analyzed four other complex phenotypes from different domains. The pattern of results is consistent with estimates of heritability obtained in twin studies carried out in the same population.

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Conflict of interest statement

Conflict of interest: The authors report no biomedical financial interests or potential conflicts of interest.

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