[Delivery in prolonged pregnancy following preparation and induction with aprofen and prednisolone]

Abstract

In 51 chronological prolonged pregnancies at 42 weeks gestation the preparation and induction was made usage of the Soviet spasmolytic preparation Aprophen. Aprophen blocks also N-cholinergic receptors in sympathetic ganglia. The tocolytic action of sympathetic system on uterine musculature was removed as well as its tonic alpha-adrenergic effect on the cervix. Thirty pregnant women were included in a control comparative group, in whom induction and preparation of labour activity was achieved by usage of corticosteroids-Prednisolone. The medication in both groups continued till beginning of labour activity, but in failure after 96 h till oxytocin indication. In 77% of women, treated with Aprophen, labour activity occurred before 96 h (40 out of 51 women but 50% of women treated with Predinisolone (15 out of 30 women)/p less than 0.02/. In 31% of women, treated with Aprophen, labour activity was induced by oxytocin stimulation (14 out of 40 women, but in 76% of women, treated with Predinisolone (10 out of 15 women)/p less than 0.05/. The high percentage of children delivered with signs of postmaturity according to Clifford in pregnant women treated with corticosteroid--23.3% against 9.8% of women treated with Aprophen (p less than 0.01) show the connection between the usage of corticosteroids and the increase of the frequency of signs of postmaturity in newborns.