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. 1990 Oct;45(7):523-7.
doi: 10.1111/j.1398-9995.1990.tb00528.x.

Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma

L Hasselmark  1 , R Malmgren, G Unge, O Zetterström
Affiliations

Lowered platelet glutathione peroxidase activity in patients with intrinsic asthma

L Hasselmark et al. Allergy. 1990 Oct.

Abstract

Platelet glutathione peroxidase (GSH-Px) activity and serum selenium (Se) levels were determined in 20 patients with intrinsic asthma. Nine of the patients had NSAID-intolerance. The mean value of GSH-Px activity in the patients was 47.0 +/- 7.1 U/10(11) platelets, which is significantly lower than that of 56.4 +/- 12 U/10(11) platelets in the controls (P less than 0.01). There was also a tendency towards lowered Se levels in the patients compared with controls. The results are discussed in view of the protective role of GSH-Px against oxidative stress and the tentative regulatory function of GSH-Px in arachidonic acid metabolism.

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