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. 2012 Mar;8(1):43-50.
doi: 10.3988/jcn.2012.8.1.43. Epub 2012 Mar 31.

Medial temporal atrophy and memory dysfunction in poststroke cognitive impairment-no dementia

Beom Joon Kim  1 , Mi-Young Oh, Myung Suk Jang, Moon-Ku Han, Jisung Lee, Juneyoung Lee, Yeonwook Kang, Kyung-Ho Yu, Byung-Chul Lee, Sangyun Kim, Byung-Woo Yoon, Hee-Joon Bae
Affiliations

Medial temporal atrophy and memory dysfunction in poststroke cognitive impairment-no dementia

Beom Joon Kim et al. J Clin Neurol. 2012 Mar.

Abstract

Background and purpose: It was recently reported that the prevalence of poststroke memory dysfunction might be higher than previously thought. Stroke may exist concomitantly with underlying Alzheimer's disease (AD), and so we determined whether post-stroke memory dysfunction indicates manifestation of underlying subclinical AD.

Methods: Of 1201 patients in a prospective cognitive assessment database, we enrolled subjects with poststroke amnestic vascular cognitive impairment-no dementia (aVCIND; n=48), poststroke nonamnestic vascular cognitive impairment-no dementia (naVCIND; n=50), and nonstroke amnestic mild cognitive impairment (aMCI; n=65). All subjects had cognitive deficits, but did not meet the criteria for dementia. A standardized neuropsychological test battery and magnetic resonance imaging were performed at least 90 days after the index stroke (mean, 473 days). Visual assessment of medial temporal atrophy (MTA) was used as a measure of underlying AD pathology.

Results: The MTA score was significantly lower in the naVCIND group (0.64±0.85, mean±SD) than in the aVCIND (1.10±1.08) and aMCI (1.45±1.13; p<0.01) groups. Multivariable ordinal logistic regression analysis revealed that compared with naVCIND, aVCIND [odds ratio (OR)=2.69; 95% confidence interval (CI)=1.21-5.99] and aMCI (OR=5.20; 95% CI=2.41-11.23) were significantly associated with increasing severity of MTA.

Conclusions: Our findings show that compared with poststroke naVCIND, the odds of having more-severe MTA were increased for poststroke aVCIND and nonstroke aMCI.

Keywords: memory dysfunction; poststroke dementia; stroke; vascular cognitive impairment.

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Conflict of interest statement

The authors have no financial conflicts of interest.

Figures

Fig. 1
Fig. 1
Recruitment of the study population. Gray boxes denote the enrolled subjects who were included in the final analyses. aVCIND: amnestic vascular cognitive impairment-no dementia, na-VCIND: nonamnestic vascular cognitive impairment-no dementia, aMCI: amnestic mild cognitive impairment.
Fig. 2
Fig. 2
Comparison of Z-scores among the three vascular cognitive impairment and no dementia (CIND) groups. aMCI: amnestic mild cognitive impairment, aVCIND: amnestic vascular cognitive impairment-no dementia, naVCIND: nonamnestic vascular cognitive impairment-no dementia.
See this image and copyright information in PMC

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