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Comment
. 2012 Jun;180(6):2201-4.
doi: 10.1016/j.ajpath.2012.03.011. Epub 2012 Apr 21.

Primary Open-Angle Glaucoma: A Transforming Growth Factor-β Pathway-Mediated Disease

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Comment

Primary Open-Angle Glaucoma: A Transforming Growth Factor-β Pathway-Mediated Disease

Andrew W Taylor. Am J Pathol. 2012 Jun.

Abstract

This Commentary highlights the article by Junglas et al (in this issue), demonstrating that connective tissue growth factor is a cause of glaucoma.

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References

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    1. AGIS Investigators The Advanced Glaucoma Intervention Study (AGIS): 7: the relationship between control of intraocular pressure and visual field deterioration. Am J Ophthalmol. 2000;130:429–440. - PubMed
    1. Fuchshofer R., Tamm E.R. The role of TGF-beta in the pathogenesis of primary open-angle glaucoma. Cell Tissue Res. 2012;347:279–290. - PubMed
    1. Junglas B., Kuespert S., Seleem A.A., Struller T., Ullmann S., Bösl M., Bosserhoff A., Köstler J., Wagner R., Tamm E.R., Fuchshofer R. Connective tissue growth factor causes glaucoma by modifying the actin cytoskeleton of the trabecular meshwork. Am J Pathol. 2012;180:2386–2403. - PubMed
    1. Shi-Wen X., Leask A., Abraham D. Regulation and function of connective tissue growth factor/CCN2 in tissue repair, scarring and fibrosis. Cytokine Growth Factor Rev. 2008;19:133–144. - PubMed

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