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. 2012 Feb;38(1):1-11, vii.
doi: 10.1016/j.rdc.2012.03.003.

Vitamin D: metabolism

Sylvia Christakos  1 , Dare V Ajibade, Puneet Dhawan, Adam J Fechner, Leila J Mady
Affiliations

Vitamin D: metabolism

Sylvia Christakos et al. Rheum Dis Clin North Am. 2012 Feb.

Abstract

The biologically active metabolite of vitamin D, 1,25(OH)(2)D(3), affects mineral homeostasis and has numerous other diverse physiologic functions including effects on growth of cancer cells and protection against certain immune disorders. This article reviews the role of vitamin D hydroxylases in providing a tightly regulated supply of 1,25(OH)(2)D(3). The role of extrarenal 1α(OH)ase in placenta and macrophages is also discussed, as well as regulation of vitamin D hydroxylases in aging and chronic kidney disease. Understanding specific factors involved in regulating the hydroxylases may lead to the design of drugs that can selectively modulate the hydroxylases. The ability to alter levels of these enzymes would have therapeutic potential for the treatment of various diseases, including bone loss disorders and certain immune diseases.

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Republished from

  • Vitamin D: metabolism.
    Christakos S, Ajibade DV, Dhawan P, Fechner AJ, Mady LJ. Christakos S, et al. Endocrinol Metab Clin North Am. 2010 Jun;39(2):243-53, table of contents. doi: 10.1016/j.ecl.2010.02.002. Endocrinol Metab Clin North Am. 2010. PMID: 20511049 Free PMC article. Review.

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