Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1979 Jul;3(3):235-42.
doi: 10.1007/BF00914180.

Regulation of bradykinin-induced cyclic amp response by quinacrine and prostaglandin E2 and F2 alpha in human synovial fibroblasts

J V Fahey, D S Newcombe

Regulation of bradykinin-induced cyclic amp response by quinacrine and prostaglandin E2 and F2 alpha in human synovial fibroblasts

J V Fahey et al. Inflammation. 1979 Jul.

Abstract

Bradykinin induces an increment in intracellular cyclic AMP concentrations of human synovial fibroblasts and evokes the release of [3H]arachidonic acid and [3H]-E prostaglandins from human synovial fibroblasts pre-labeled in their phospholipids. Both these bradykinin-induced reactions are inhibited by quinacrine, an inhibitor of phospholipase A activity. The cyclic AMP response of human synovial fibroblasts to bradykinin is potentiated by prostaglandin E2 and inhibited by prostaglandin F2 alpha. These data emphasize the critical role of the prostaglandin system in reactions induced by bradykinin and suggest mechansims by which inflammatory reactions due to bradykinin may be modulated.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. J Biol Chem. 1977 Feb 25;252(4):1408-13 - PubMed
    1. J Biol Chem. 1976 Feb 10;251(3):776-80 - PubMed
    1. Life Sci. 1977 Mar 15;20(6):903-13 - PubMed
    1. J Biol Chem. 1976 Sep 25;251(18):5814-6 - PubMed
    1. Br J Exp Pathol. 1970 Jun;51(3):322-7 - PubMed

LinkOut - more resources